The cellular prion protein binds copper in vivo

David R. Brown, Kefeng Qin, Jochen Herms, +10

Nature

BiochemistryNatural SciencesMetalloproteinBioactive MetalMolecular Biology +3

Copper(II)-induced Conformational Changes and Protease Resistance in Recombinant and Cellular PrP

Kefeng Qin, Dun‐Sheng Yang, Ying Yang, +6

Journal of Biological Chemistry

Mapping Cu(II) Binding Sites in Prion Proteins by Diethyl Pyrocarbonate Modification and Matrix-assisted Laser Desorption Ionization-Time of Flight (MALDI-TOF) Mass Spectrometric Footprinting

Kefeng Qin, Ying Yang, Peter Mastrangelo, +1

Journal of Biological Chemistry

Doppel Is an N-Glycosylated, Glycosylphosphatidylinositol-anchored Protein

Gregory L. Silverman, Kefeng Qin, Richard C. Moore, +6

Journal of Biological Chemistry

GlycobiologyMolecular BiologyProtein ExpressionPrion DiseaseGlycosylphosphatidylinositol-anchored Protein +15

Rapamycin Delays Disease Onset and Prevents PrP Plaque Deposition in a Mouse Model of Gerstmann–Sträussler–Scheinker Disease

Constanza J. Cortés, Kefeng Qin, Julie Cook, +2

Journal of Neuroscience

MitophagyImmunologyPathologyCell DeathProminent Ataxia +21

Protective effects of ginsenoside Rd against okadaic acid-induced neurotoxicity in vivo and in vitro

Ling Li, Juanfang Liu, Xiaodong Yan, +6

Journal of Ethnopharmacology

Pharmacological StudyMedicineOkadaic Acid-induced NeurotoxicityHerb-drug InteractionPhytopharmacology +7

Ginsennoside Rd Attenuates Cognitive Dysfunction in a Rat Model of Alzheimer’s Disease

Juanfang Liu, Xiaodong Yan, Ling Li, +6

Neurochemical Research

Neurodegenerative DiseasesAlzheimer's DiseaseMedicineNeuropharmacologyDegenerative Pathology +8

Phosphatase Type 2A-dependent and -independent Pathways for ATR Phosphorylation of Chk1

Ge Li, Robert T. Elder, Kefeng Qin, +3

Journal of Biological Chemistry

Atr PhosphorylationMolecular BiologyCell CycleRegulatory Kinase-Independent Pathways +16

The PrP-like Protein Doppel Binds Copper

Kefeng Qin, Janaky Coomaraswamy, Peter Mastrangelo, +8

Journal of Biological Chemistry

Protein ChemistryFluorescence QuenchingBioactive MetalBiochemistryDpl Peptide +12

Generation of human chronic wasting disease in transgenic mice

Zerui Wang, Kefeng Qin, Manuel V. Camacho, +7

Acta Neuropathologica Communications