Javier Apfeld

aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

Ross S. Francis, Garth McGrath, Jianhua Zhang et al. · Developmental Cell · 2002 · 794 citations · Full text

Protein Function, Signal Transduction, γ-Secretase Cleavage +9

Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

Laura Bordone, Maria Carla Motta, Frédéric Picard et al. · PLoS Biology · 2005 · 702 citations · Full text

Insulin Signaling, Metabolic Syndrome, Signaling Pathway +16

The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in <i>C. elegans</i>

Javier Apfeld, Greg O’Connor, Tom McDonagh et al. · Genes & Development · 2004 · 634 citations · Full text

Regulation of lifespan by sensory perception in Caenorhabditis elegans

Javier Apfeld, Cynthia Kenyon · Nature · 1999 · 567 citations

Biology, Neural Mechanism, Longevity +5

Regulation of Life-Span by Germ-Line Stem Cells in <i>Caenorhabditis elegans</i>

Nuno Arantes-Oliveira, Javier Apfeld, Andrew Dillin et al. · Science · 2002 · 515 citations

Aging, Reproductive Biology, Stem Cell Biology +20