Concepedia

Braf V600e Mutation

The "BRAF V600E Mutation" is a specific somatic point mutation in the BRAF gene characterized by a valine-to-glutamate substitution at codon 600, resulting in constitutive activation of the MAPK signaling pathway and commonly associated with various histiocytic disorders.

2.6K

Publications

226.7K

Citations

18.1K

Authors

3.2K

Institutions

Publications per year

2017–2026

1.1K

Variants

Braf V600e

Parents

Publications

2.6K

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations

, , +12

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

Paul B. Chapman, Axel Hauschild, Caroline Robert et al. · New England Journal of Medicine · 2011 · 7.7K citations · Full text

, , +9

Nivolumab in Previously Untreated Melanoma without <i>BRAF</i> Mutation

Caroline Robert, Georgina V. Long, Benjamin Brady et al. · New England Journal of Medicine · 2014 · 5.4K citations · Full text

, , +14

BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

Scott M. Wilhelm, Christopher Carter, LiYa Tang et al. · Cancer Research · 2004 · 4K citations · Full text

, , +17

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

Keith T. Flaherty, Igor Puzanov, Kevin B. Kim et al. · New England Journal of Medicine · 2010 · 3.5K citations

, , +17

1–5 of 2.6K

Authors

18.1K

  1. GV
    Georgina V. Long

    The University of Sydney, Australia

    47 publications · 19.6K citations

    34

    h-index

  2. KT
    Keith T. Flaherty

    Massachusetts General Hospital, United States

    43 publications · 26.2K citations

    32

    h-index

  3. AV
    Andreas von Deimling

    Heidelberg University, Germany

    34 publications · 5.8K citations

    30

    h-index

  4. DC
    David Capper

    Heidelberg University, Germany

    34 publications · 5K citations

    29

    h-index

  5. AR
    Antoni Ribas

    University of California, Los Angeles, United States

    37 publications · 25.7K citations

    28

    h-index

1–5 of 18.1K

Institutions

3.2K

  1. The University of Texas MD Anderson Cancer Center

    Houston, United States

    58 h-index

    706 publications

    98K citations

  2. Massachusetts General Hospital

    Boston, United States

    58 h-index

    368 publications

    92K citations

  3. Memorial Sloan Kettering Cancer Center

    New York, United States

    57 h-index

    567 publications

    99.5K citations

  4. Heidelberg University

    Heidelberg, Germany

    53 h-index

    433 publications

    70.4K citations

  5. Harvard University

    Cambridge, United States

    49 h-index

    484 publications

    92.4K citations

  6. German Cancer Research Center

    Heidelberg, Germany

    49 h-index

    307 publications

    47.2K citations

  7. Johns Hopkins University

    Baltimore, United States

    48 h-index

    474 publications

    73K citations

  8. Inserm

    Paris, France

    41 h-index

    380 publications

    39.9K citations

1–8 of 3.2K

Venues

  1. Journal of Clinical Oncology

    120 publications · 15.9K citations

    50

    h-index

  2. Clinical Cancer Research

    54 publications · 8K citations

    44

    h-index

  3. The Journal of Clinical Endocrinology & Metabolism

    JCEM · 43 publications · 7.7K citations

    39

    h-index

  4. Oncotarget

    59 publications · 2.6K citations

    30

    h-index

  5. Thyroid

    38 publications · 2.6K citations

    29

    h-index

1–5