Concepedia

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

Joseph S. Warmus, Cathlin Flamme, Lu Yan Zhang, Stephen D. Barrett, Alexander J. Bridges, Huifen Chen, Richard Gowan, Michael D. Kaufman, Judy Sebolt-Leopold, Wilbur R. Leopold,

Bioorganic & Medicinal Chemistry Letters · 2008 · 67 citations · 12 references

DOI

Concepts

References

12

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

Judith S. Sebolt–Leopold, David T. Dudley, Román Herrera et al. · Nature Medicine · 1999 · 969 citations

, , +14

Organic Fluorine Hardly Ever Accepts Hydrogen Bonds

Jack D. Dunitz, Robin Taylor · Chemistry - A European Journal · 1997 · 928 citations

, , +17

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Jeffrey F. Ohren, Huifen Chen, A.G. Pavlovsky et al. · Nature Structural & Molecular Biology · 2004 · 621 citations

, , +9

Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles

Ali Almasirad, Sayyed Abbas Tabatabai, Mehrdad Faizi et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 360 citations

, , +9

Fluorine Interactions at the Thrombin Active Site: Protein Backbone Fragments HC<sub>α</sub>CO Comprise a Favorable CF Environment and Interactions of CF with Electrophiles

Jacob Olsen, David W. Banner, Paul Seiler et al. · ChemBioChem · 2004 · 148 citations

, , +17