Richard Gowan

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

Judith S. Sebolt–Leopold, David T. Dudley, Román Herrera et al. · Nature Medicine · 1999 · 969 citations

Medicine, Cancer Biology, Oncology +14

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

Joseph S. Warmus, Cathlin Flamme, Lu Yan Zhang et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 67 citations

Medicine, Medicinal Chemistry, Pharmacology +9

4-Anilino-5-carboxamido-2-pyridone Derivatives as Noncompetitive Inhibitors of Mitogen-Activated Protein Kinase Kinase

Julie A. Spicer, Gordon W. Rewcastle, Michael D. Kaufman et al. · Journal of Medicinal Chemistry · 2007 · 50 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Structure−Activity Relationships of Cysteine-Lacking Pentapeptide Derivatives That Inhibit ras Farnesyltransferase

Daniele M. Leonard, Kevon R. Shuler, Cynthia J. Poulter et al. · Journal of Medicinal Chemistry · 1997 · 39 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

C-Terminal Modifications of Histidyl-<i>N</i>-benzylglycinamides To Give Improved Inhibition of Ras Farnesyltransferase, Cellular Activity, and Anticancer Activity in Mice

Dennis J. McNamara, Ellen M. Dobrusin, Daniele M. Leonard et al. · Journal of Medicinal Chemistry · 1997 · 27 citations · Full text

Medicine, Oncology, Pharmacology +8