Judith S. Sebolt–Leopold

BRAF mutation predicts sensitivity to MEK inhibition

David B. Solit, Levi A. Garraway, Christine A. Pratilas et al. · Nature · 2005 · 1.3K citations · Full text

Life Sciences, Genetics, Molecular Biology +10

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

Judith S. Sebolt–Leopold, David T. Dudley, Román Herrera et al. · Nature Medicine · 1999 · 969 citations

Medicine, Cancer Biology, Oncology +14

Multicenter Phase II Study of the Oral MEK Inhibitor, CI-1040, in Patients With Advanced Non-Small-Cell Lung, Breast, Colon, and Pancreatic Cancer

John J. Rinehart, Alex A. Adjei, Patricia LoRusso et al. · Journal of Clinical Oncology · 2004 · 639 citations

Medicine, Oncology, Pharmacology +16

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Jeffrey F. Ohren, Huifen Chen, A.G. Pavlovsky et al. · Nature Structural & Molecular Biology · 2004 · 621 citations

Life Sciences, Biochemistry, Molecular Biology +9

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

Kevin M. Haigis, K Kendall, Yufang Wang et al. · Nature Genetics · 2008 · 601 citations

Medicine, Cancer Biology, Oncology +16