Cathlin Flamme

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Jeffrey F. Ohren, Huifen Chen, A.G. Pavlovsky et al. · Nature Structural & Molecular Biology · 2004 · 612 citations

Signal Transduction, Signaling Pathway, Cell Regulation +8

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Stephen D. Barrett, Alexander J. Bridges, David T. Dudley et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 280 citations

Medicinal Chemistry, Drug Target, Biochemistry +10

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

Joseph S. Warmus, Cathlin Flamme, Lu Yan Zhang et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 67 citations

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +9

4-Anilino-5-carboxamido-2-pyridone Derivatives as Noncompetitive Inhibitors of Mitogen-Activated Protein Kinase Kinase

Julie A. Spicer, Gordon W. Rewcastle, Michael D. Kaufman et al. · Journal of Medicinal Chemistry · 2007 · 48 citations · Full text