Concepedia

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Stephen D. Barrett, Alexander J. Bridges, David T. Dudley, Alan R. Saltiel, James H. Fergus, Cathlin Flamme, Amy M. Delaney, Michael D. Kaufman, S Lepage, Wilbur R. Leopold,

Bioorganic & Medicinal Chemistry Letters · 2008 · 286 citations · 10 references

DOI

Concepts

References

10

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

David T. Dudley, Long Pang, Stuart J. Decker et al. · Proceedings of the National Academy of Sciences · 1995 · 2.7K citations · Full text

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Identification of the regulatory phosphorylation sites in pp42/mitogen‐activated protein kinase (MAP kinase).

D. Michael Payne, Anthony Rossomando, P. A. Martino et al. · The EMBO Journal · 1991 · 1K citations · Full text

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Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

Judith S. Sebolt–Leopold, David T. Dudley, Román Herrera et al. · Nature Medicine · 1999 · 969 citations

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Organic Fluorine Hardly Ever Accepts Hydrogen Bonds

Jack D. Dunitz, Robin Taylor · Chemistry - A European Journal · 1997 · 928 citations

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Multicenter Phase II Study of the Oral MEK Inhibitor, CI-1040, in Patients With Advanced Non-Small-Cell Lung, Breast, Colon, and Pancreatic Cancer

John J. Rinehart, Alex A. Adjei, Patricia LoRusso et al. · Journal of Clinical Oncology · 2004 · 639 citations

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