S Lepage

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Stephen D. Barrett, Alexander J. Bridges, David T. Dudley et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 286 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9

Role of the conserved amino acids of the ‘SDN’ loop (Ser130, Asp131 and Asn132) in a class A <i>β</i>-lactamase studied by site-directed mutagenesis

F Jacob, Bernard Joris, S Lepage et al. · Biochemical Journal · 1990 · 110 citations · Full text

Life Sciences, Biochemistry, Microbiology +17

Synthesis, purification and kinetic properties of fluorescein-labelled penicillins

Bernard Lakaye, Christian Damblon, Marc Jamin et al. · Biochemical Journal · 1994 · 63 citations · Full text

Life Sciences, Biochemistry, Microbiology +9

The penicillin sensory transducer, BlaR, involved in the inducibility of β‐lactamase synthesis in <i>Bacillus licheniformis</i> is embedded in the plasma membrane via a four‐α‐helix bundle

Karin Hardt, Bernard Joris, S Lepage et al. · Molecular Microbiology · 1997 · 53 citations · Full text

Life Sciences, Microbiology, Molecular Biology +17

When drug inactivation renders the target irrelevant to antibiotic resistance: a case story with β‐lactams

Bernard Lakaye, Alain Dubus, S Lepage et al. · Molecular Microbiology · 1999 · 43 citations

Life Sciences, Microbiology, Antimicrobial Pharmacology +16