Stephen D. Barrett

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

Judith S. Sebolt–Leopold, David T. Dudley, Román Herrera et al. · Nature Medicine · 1999 · 969 citations

Medicine, Cancer Biology, Oncology +14

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Jeffrey F. Ohren, Huifen Chen, A.G. Pavlovsky et al. · Nature Structural & Molecular Biology · 2004 · 621 citations

Life Sciences, Biochemistry, Molecular Biology +9

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Stephen D. Barrett, Alexander J. Bridges, David T. Dudley et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 286 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9

Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: Potential proinflammatory mechanisms

Melissa Thiel, Caralee Schaefer, Mark E. Lesch et al. · Arthritis & Rheumatism · 2007 · 102 citations · Full text

Medicine, Immunology, Pharmacology +17

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

Joseph S. Warmus, Cathlin Flamme, Lu Yan Zhang et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 67 citations

Medicine, Medicinal Chemistry, Pharmacology +9