Stephen D. Barrett

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

Judith S. Sebolt–Leopold, David T. Dudley, Román Herrera et al. · Nature Medicine · 1999 · 965 citations

Colon Tumors, Medicine, Receptor Tyrosine Kinase +9

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Jeffrey F. Ohren, Huifen Chen, A.G. Pavlovsky et al. · Nature Structural & Molecular Biology · 2004 · 612 citations

Signal Transduction, Signaling Pathway, Cell Regulation +8

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Stephen D. Barrett, Alexander J. Bridges, David T. Dudley et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 280 citations

Medicinal Chemistry, Drug Target, Biochemistry +10

Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: Potential proinflammatory mechanisms

Melissa Thiel, Caralee Schaefer, Mark E. Lesch et al. · Arthritis & Rheumatism · 2007 · 99 citations · Full text

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

Joseph S. Warmus, Cathlin Flamme, Lu Yan Zhang et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 67 citations

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +9