Alexander J. Bridges

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

David T. Dudley, Long Pang, Stuart J. Decker et al. · Proceedings of the National Academy of Sciences · 1995 · 2.7K citations · Full text

Signal Transduction, Pd 098059, Cell Regulation +14

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

Judith S. Sebolt–Leopold, David T. Dudley, Román Herrera et al. · Nature Medicine · 1999 · 965 citations

Colon Tumors, Medicine, Receptor Tyrosine Kinase +9

A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

David W. Fry, Alan J. Kraker, Amy McMichael et al. · Science · 1994 · 801 citations

Specific Inhibitor, Cancer Research, Signal Transduction +13

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

David W. Fry, Alexander J. Bridges, William A. Denny et al. · Proceedings of the National Academy of Sciences · 1998 · 417 citations

Drug Target, Cell Growth, Chemical Biology +21

Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure−Activity Relationship for Analogues of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent Inhibitor of the Epidermal Growth Factor Receptor

Alexander J. Bridges, Hairong Zhou, Donna R. Cody et al. · Journal of Medicinal Chemistry · 1996 · 321 citations · Full text