Molecules · 2017 · 56 citations · 32 references
Life SciencesBiochemistryBotanyMycologyNatural Product BiosynthesisPlant BiochemistryFlavonoid BiosynthesisFungal MetabolismFungal Natural Product BiosynthesisGlycan BiosynthesisMicrobial BiotransformationPlant Natural Product BiosynthesisBiotransformationFlavonoid GlycosylationFungal Bioactive CompoundsFungal GlycosylationFungal Metabolite BiosynthesisGlycosylation Of Natural ProductsMicrobial GlycosylationNatural Product Glycosylation
Biotransformation of daidzein, genistein and biochanin A by three selected filamentous fungi was investigated. As a result of biotransformations, six glycosylation products were obtained. Fungus Beauveria bassiana converted all tested isoflavones to 4″-O-methyl-7-O-glucosyl derivatives, whereas Absidia coerulea and Absidia glauca were able to transform genistein and biochanin A to genistin and sissotrin, respectively. In the culture of Absidia coerulea, in addition to the sissotrin, the product of glucosylation at position 5 was formed. Two of the obtained compounds have not been published so far: 4″-O-methyl-7-O-glucosyl biochanin A and 5-O-glucosyl biochanin A (isosissotrin). Biotransformation products were obtained with 22%–40% isolated yield.
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