Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor - Concepedia

Concepedia

Publication | Open Access

Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor

DOI Full Paper Access

575

Citations

24

References

2007

Year

Tammie C. Yeh, Vivienne Marsh, Bryan A. Bernat, Josh Ballard, Heidi Colwell, R J Evans, Janet Parry, Darin Smith, Barbara J. Brandhuber, Allison Marlow,

Clinical Cancer Research

Abstract

ARRY-142886 is a potent and selective MEK1/2 inhibitor that is highly active in both in vitro and in vivo tumor models. This compound is currently being investigated in clinical studies.

References

	Year	Citations

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