Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor

Tammie C. Yeh, Vivienne Marsh, Bryan A. Bernat, +13

Clinical Cancer Research

Identification of the Clinical Development Candidate <b>MRTX849</b>, a Covalent KRAS^G12C Inhibitor for the Treatment of Cancer

Jay B. Fell, John P. Fischer, Brian R. Baer, +31

Journal of Medicinal Chemistry

Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling

Jacob R. Haling, Jawahar Sudhamsu, Ivana Yen, +12

Cancer Cell

Braf-mek ComplexSignal TransductionSignaling PathwayCell RegulationReceptor Tyrosine Kinase +5

A Long-Acting, Highly Potent Interferon α-2 Conjugate Created Using Site-Specific PEGylation

Mary S. Rosendahl, Daniel H. Doherty, Darin Smith, +3

Bioconjugate Chemistry

Ethylene GlycolBiochemistryNatural SciencesMedicineSmall Molecules +12

Site-Specific PEGylation of Engineered Cysteine Analogues of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor

Daniel H. Doherty, Mary S. Rosendahl, Darin Smith, +3

Bioconjugate Chemistry

EngineeringImmunologySite-specific PegylationInflammationGm-csf Cysteine Analogues +17

Spirocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species

Kevin W. Hunt, Adam W. Cook, Ryan J. Watts, +23

Journal of Medicinal Chemistry

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors

Allen A. Thomas, Yvan Le Huérou, Jason De Meese, +22

Bioorganic & Medicinal Chemistry Letters

Vivo ActivityBiochemistryMedicineMechanism Of ActionPharmacological Agent +5

A Long-Acting, Mono-PEGylated Human Growth Hormone Analog Is a Potent Stimulator of Weight Gain and Bone Growth in Hypophysectomized Rats

George N. Cox, Mary S. Rosendahl, Elizabeth A. Chlipala, +3

Endocrinology

Human GrowthRecombinant Human GhOsteoporosisLong Half-lifeBone Homeostasis +19

Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2

Laurel M. Pegram, Jennifer Liddle, Yao Xiao, +9

Proceedings of the National Academy of Sciences

Molecular BiologyCompetent Active SiteConformational SelectionActivation Loop DynamicsProtein Folding +17

Enhanced circulating half-life and hematopoietic properties of a human granulocyte colony-stimulating factor/immunoglobulin fusion protein

George N. Cox, Darin Smith, Sharon J. Carlson, +3

Experimental Hematology

Autoimmune DiseaseGranulocyteHematopoietic PropertiesHematologyImmunology +6