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Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)

Jonathan T. Seal, Yann Lamotte, Frédéric Donche, Anne Bouillot, Olivier Mirguet, Françoise Gellibert, Edwige Nicodème, Gaël Krysa, Jorge Kirilovsky, Sören Beinke,

Bioorganic & Medicinal Chemistry Letters · 2012 · 213 citations · 8 references

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8

Suppression of inflammation by a synthetic histone mimic

Edwige Nicodème, Kate L. Jeffrey, Uwe Schaefer et al. · Nature · 2010 · 1.6K citations · Full text

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Mark A. Dawson, Rab K. Prinjha, Antje Dittmann et al. · Nature · 2011 · 1.5K citations · Full text

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Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

Chun‐wa Chung, Hervé Coste, Julia H. White et al. · Journal of Medicinal Chemistry · 2011 · 335 citations · Full text

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3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands

David S. Hewings, Minghua Wang, Martin Philpott et al. · Journal of Medicinal Chemistry · 2011 · 223 citations · Full text

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Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides

Paul Bamborough, Hawa Diallo, Jonathan D. Goodacre et al. · Journal of Medicinal Chemistry · 2011 · 176 citations · Full text

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