Concepedia

Protein-ligand Binding

Protein-Ligand Binding is a biochemical interaction in which a protein, as the macromolecular host, selectively associates with a small molecule or ion—termed a ligand—through non-covalent forces, thereby forming a stable complex that underlies molecular recognition in biological systems.

20.1K

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1.4M

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69.2K

Authors

7K

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2017–2026

4.6K

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Publications

20.1K

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

Garrett M. Morris, Ruth Huey, William Lindstrom et al. · Journal of Computational Chemistry · 2009 · 25K citations · Full text

, , +13

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

George Scatchard · Annals of the New York Academy of Sciences · 1949 · 19.9K citations

, , +9

Glide:  A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy

Richard A. Friesner, Jay L. Banks, Robert B. Murphy et al. · Journal of Medicinal Chemistry · 2004 · 9.9K citations

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LIGAND: A versatile computerized approach for characterization of ligand-binding systems

Peter J. Munson, David Rodbard · Analytical Biochemistry · 1980 · 8.5K citations

, , +11

Extra Precision Glide:  Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes

Richard A. Friesner, Robert B. Murphy, Matthew P. Repasky et al. · Journal of Medicinal Chemistry · 2006 · 6.9K citations

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1–5 of 20.1K

Authors

69.2K

  1. JS
    John S. Olson

    Rice University, United States

    48 publications · 3.7K citations

    33

    h-index

  2. JA
    J. Andrew McCammon

    University of California San Diego, United States

    39 publications · 3.4K citations

    32

    h-index

  3. TA
    Timothy A. Springer

    Harvard University, United States

    33 publications · 2.6K citations

    29

    h-index

  4. GK
    G. Klebe

    Philipps University of Marburg, Germany

    37 publications · 4.7K citations

    28

    h-index

  5. GU
    G. Ulrich Nienhaus

    University of Illinois Urbana-Champaign, United States

    33 publications · 2.8K citations

    27

    h-index

1–5 of 69.2K

Institutions

7K

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    98 h-index

    284 publications

    37.3K citations

  2. Harvard University

    Cambridge, United States

    96 h-index

    324 publications

    32.4K citations

  3. Scripps Research Institute

    San Diego, United States

    89 h-index

    264 publications

    62K citations

  4. National Institutes of Health

    Bethesda, United States

    84 h-index

    299 publications

    32.1K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    83 h-index

    566 publications

    29.8K citations

  6. University of California, San Francisco

    San Francisco, United States

    82 h-index

    208 publications

    33.4K citations

  7. University of California San Diego

    San Diego, United States

    73 h-index

    232 publications

    44.2K citations

  8. University of Oxford

    Oxford, United Kingdom

    72 h-index

    254 publications

    19K citations

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  1. Journal of Biological Chemistry

    JBC · 1.4K publications · 110.1K citations

    152

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  2. Proceedings of the National Academy of Sciences

    PNAS · 595 publications · 73.7K citations

    146

    h-index

  3. Journal of the American Chemical Society

    JACS · 735 publications · 69.5K citations

    132

    h-index

  4. Biochemistry

    1K publications · 62.2K citations

    110

    h-index

  5. Journal of Medicinal Chemistry

    402 publications · 54.3K citations

    94

    h-index

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