Concepedia

Enzyme-inhibitor Binding

Enzyme-Inhibitor Binding is a type of protein-ligand binding in which a small molecule selectively interacts with an enzyme to reduce or block its catalytic activity, distinguishing it from other ligand interactions by its functional consequence of enzymatic inhibition.

1.8K

Publications

104.9K

Citations

8.1K

Authors

1.7K

Institutions

Publications per year

2017–2026

227

Parents

Publications

1.8K

The determination of enzyme inhibitor constants

Martin Dixon · Biochemical Journal · 1953 · 4.1K citations · Full text

, , +15

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

Andrew S. Dixon, Marie K. Schwinn, Mary P. Hall et al. · ACS Chemical Biology · 2015 · 1.5K citations · Full text

, , +17

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists.

Robert A. Copeland · PubMed · 2005 · 1.1K citations

, , +17

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

Haitao Yang, Maojun Yang, Yi Ding et al. · Proceedings of the National Academy of Sciences · 2003 · 1.1K citations · Full text

, , +17

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

Cheryl Lyons, Gregory Orloff, James M. Cunningham · Journal of Biological Chemistry · 1992 · 870 citations · Full text

, , +12

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Authors

8.1K

  1. DW
    David W. Christianson

    University of Pennsylvania, United States

    14 publications · 893 citations

    14

    h-index

  2. RH
    Robert Huber

    Max Planck Institute of Biochemistry, Germany

    11 publications · 759 citations

    11

    h-index

  3. PT
    Palmer Taylor

    University of California San Diego, United States

    10 publications · 1.3K citations

    10

    h-index

  4. WB
    Wolfram Bode

    Max Planck Institute of Biochemistry, Germany

    9 publications · 1.2K citations

    9

    h-index

  5. VL
    Vern L. Schramm

    Albert Einstein College of Medicine, United States

    9 publications · 364 citations

    9

    h-index

1–5 of 8.1K

Institutions

1.7K

  1. Centre National de la Recherche Scientifique

    Paris, France

    23 h-index

    152 publications

    7K citations

  2. University of California San Diego

    San Diego, United States

    21 h-index

    70 publications

    5.3K citations

  3. Harvard University

    Cambridge, United States

    19 h-index

    62 publications

    4.1K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    19 h-index

    69 publications

    9.7K citations

  5. National Institutes of Health

    Bethesda, United States

    18 h-index

    78 publications

    9K citations

  6. University of Michigan

    Ann Arbor, United States

    18 h-index

    86 publications

    3.8K citations

  7. Scripps Research Institute

    San Diego, United States

    18 h-index

    89 publications

    9.7K citations

  8. University of Oxford

    Oxford, United Kingdom

    18 h-index

    101 publications

    8.6K citations

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Venues

  1. Journal of Biological Chemistry

    JBC · 217 publications · 17.1K citations

    73

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  2. Biochemistry

    178 publications · 8.7K citations

    57

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  3. Proceedings of the National Academy of Sciences

    PNAS · 62 publications · 9.9K citations

    45

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  4. Journal of Medicinal Chemistry

    82 publications · 5.2K citations

    42

    h-index

  5. Biochemical Journal

    BJ · 67 publications · 3.4K citations

    37

    h-index

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