Concepedia

Ligand-induced Stabilization

Ligand-Induced Stabilization is a biophysical phenomenon in which the binding of a ligand to a protein selectively enhances the structural stability of the protein by reducing its conformational entropy or dynamic fluctuations, thereby shifting the equilibrium toward a more thermodynamically stable state.

151

Publications

12.9K

Citations

810

Authors

297

Institutions

Publications per year

2017–2026

32

Parents

Publications

151

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

F. Niesen, H. Berglund, Masoud Vedadi · Nature Protocols · 2007 · 2.4K citations

, , +14

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

Daniel Martinez Molina, Rozbeh Jafari, Marina Ignatushchenko et al. · Science · 2013 · 2.2K citations

, , +17

High-Density Miniaturized Thermal Shift Assays as a General Strategy for Drug Discovery

Michael W. Pantoliano, Eugene C. Petrella, Joseph D. Kwasnoski et al. · SLAS DISCOVERY · 2001 · 885 citations · Full text

, , +15

A Quantitative Model of Thermal Stabilization and Destabilization of Proteins by Ligands

P. Cimmperman, Lina Baranauskienė, Simona Jachimovičiūtė et al. · Biophysical Journal · 2008 · 345 citations · Full text

, , +14

Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand

Łukasz Jaremko, Mariusz Jaremko, Karin Giller et al. · Science · 2014 · 252 citations

, , +17

1–5 of 151

Authors

810

  1. MB
    Maurizio Brunori

    Sapienza University of Rome, Italy

    4 publications · 121 citations

    4

    h-index

  2. FC
    Francesca Cutruzzolà

    Sapienza University of Rome, Italy

    3 publications · 88 citations

    3

    h-index

  3. JM
    Jean‐Louis Mergny

    Inserm, France

    3 publications · 67 citations

    3

    h-index

  4. PA
    Paolo Ascenzi

    Roma Tre University, Italy

    3 publications · 85 citations

    3

    h-index

  5. MB
    Martino Bolognesi

    University of Milan, Italy

    3 publications · 85 citations

    3

    h-index

1–5 of 810

Institutions

297

  1. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    35 publications

    1.4K citations

  2. Karolinska Institutet

    Stockholm, Sweden

    6 h-index

    20 publications

    16.2K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    6 h-index

    23 publications

    1.2K citations

  4. Inserm

    Paris, France

    5 h-index

    30 publications

    719 citations

  5. Freie Universität Berlin

    Berlin, Germany

    4 h-index

    7 publications

    233 citations

  6. Université de Bordeaux

    Bordeaux, France

    3 h-index

    20 publications

    428 citations

  7. National Institutes of Health

    Bethesda, United States

    3 h-index

    7 publications

    236 citations

  8. Consejo Superior de Investigaciones Científicas

    Madrid, Spain

    3 h-index

    14 publications

    877 citations

1–8 of 297

Venues

  1. Biochemistry

    16 publications · 636 citations

    14

    h-index

  2. Journal of Biological Chemistry

    JBC · 14 publications · 667 citations

    13

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 9 publications · 466 citations

    9

    h-index

  4. Journal of Molecular Biology

    JMB · 6 publications · 595 citations

    6

    h-index

  5. Journal of the American Chemical Society

    JACS · 5 publications · 353 citations

    5

    h-index

1–5