High-Density Miniaturized Thermal Shift Assays as a General Strategy for Drug Discovery

Michael W. Pantoliano, Eugene C. Petrella, Joseph D. Kwasnoski, +8

SLAS DISCOVERY

Pharmaceutical ResearchGeneral StrategyEngineeringBioanalysisAnalytical Chemistry +9

Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

Bruce Grasberger, Tianbao Lu, Carsten J. Schubert, +23

Journal of Medicinal Chemistry

Molecular BiologyChemical BiologyPharmaceutical ChemistryTumor BiologyMolecular Pharmacology +18

Natural products reveal cancer cell dependence on oxysterol-binding proteins

Anthony W. G. Burgett, Thomas B. Poulsen, Kittikhun Wangkanont, +14

Nature Chemical Biology

BiochemistryOncogenic AgentMedicineOxysterol-binding ProteinsCancer Biology +3

Phospholipid/Alkanethiol Bilayers for Cell-Surface Receptor Studies by Surface Plasmon Resonance

Anne L. Plant, Michael Brigham‐Burke, Eugene C. Petrella, +1

Analytical Biochemistry

Proteinlipid InteractionEngineeringBiochemistryBiomedical DiagnosticsBiosensing Systems +9

1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2–p53 interaction: discovery and SAR

Daniel J. Parks, Louis V. LaFrance, Raul R. Calvo, +10

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyDrug TargetSmall Molecule AntagonistsMedicineNatural Sciences +9

Structural Requirements and Thermodynamics of the Interaction of Proline Peptides with Profilin

Eugene C. Petrella, Laura M. Machesky, Thomas D. Pollard

Biochemistry

The Three-dimensional Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine

Lei Jin, Scott Pluskey, Eugene C. Petrella, +8

Journal of Biological Chemistry

High-Density Miniaturized Thermal Shift Assays as a General Strategy for Drug Discovery

Michael W. Pantoliano, Eugene C. Petrella, Joseph D. Kwasnoski, +8

Journal of biomolecular screening

Pharmaceutical ResearchGeneral StrategyEngineeringBioanalysisAnalytical Chemistry +9

Antibody-mediated complement activation on nucleated cells. A quantitative analysis of the individual reaction steps.

Markus Ollert, Jan Kadlec, Kerstin A. David, +3

The Journal of Immunology

Antibody-mediated Complement ActivationLaboratory ImmunologyImmunologyMolecular BiologyMembrane Attack Phases +23

Primary structure of cobra complement component C3

David C. Fritzinger, Eugene C. Petrella, M B Connelly, +2

The Journal of Immunology