Concepedia

1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2–p53 interaction: discovery and SAR

Daniel J. Parks, Louis V. LaFrance, Raul R. Calvo, Karen L. Milkiewicz, Varsha Gupta, Jennifer Lattanze, Kannan Ramachandren, Theodore E. Carver, Eugene C. Petrella, Maxwell D. Cummings,

Bioorganic & Medicinal Chemistry Letters · 2004 · 167 citations · 16 references

DOI

Concepts

References

16

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

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High-Density Miniaturized Thermal Shift Assays as a General Strategy for Drug Discovery

Michael W. Pantoliano, Eugene C. Petrella, Joseph D. Kwasnoski et al. · SLAS DISCOVERY · 2001 · 885 citations · Full text

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MDM2, an introduction.

Tomoo Iwakuma, Guillermina Lozano · PubMed · 2003 · 391 citations

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Helical β-Peptide Inhibitors of the p53-hDM2 Interaction

Joshua A. Kritzer, James D. Lear, Michael E. Hodsdon et al. · Journal of the American Chemical Society · 2004 · 311 citations

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Postcondensation Modifications of Ugi Four-Component Condensation Products:  1-Isocyanocyclohexene as a Convertible Isocyanide. Mechanism of Conversion, Synthesis of Diverse Structures, and Demonstration of Resin Capture

Thomas A. Keating, Robert W. Armstrong · Journal of the American Chemical Society · 1996 · 288 citations

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