Theodore E. Carver

Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

Bruce Grasberger, Tianbao Lu, Carsten J. Schubert et al. · Journal of Medicinal Chemistry · 2005 · 425 citations · Full text

Molecular Biology, Chemical Biology, Pharmaceutical Chemistry +20

The effects of amino acid substitution at position E7 (residue 64) on the kinetics of ligand binding to sperm whale myoglobin.

Ronald J. Rohlfs, Antony J. Mathews, Theodore E. Carver et al. · Journal of Biological Chemistry · 1990 · 288 citations · Full text

Position E7, Molecular Biology, Amino Acid Substitution +16

A novel site-directed mutant of myoglobin with an unusually high O2 affinity and low autooxidation rate.

Theodore E. Carver, REBEKAH BRANTLEY, Eileen W. Singleton et al. · Journal of Biological Chemistry · 1992 · 212 citations · Full text

Protein Assembly, Molecular Biology, Helix Notation +18

Analysis of the kinetic barriers for ligand binding to sperm whale myoglobin using site-directed mutagenesis and laser photolysis techniques.

Theodore E. Carver, Ronald J. Rohlfs, John S. Olson et al. · Journal of Biological Chemistry · 1990 · 183 citations · Full text

Amino Acids, Photochemistry, Biochemistry +15

1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2–p53 interaction: discovery and SAR

Daniel J. Parks, Louis V. LaFrance, Raul R. Calvo et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 166 citations

Molecular Pharmacology, Drug Target, Small Molecule Antagonists +11