Concepedia

Bruce Grasberger

BG

Statistics

Publications

16

Citations

1.6K

H-Index

14

Active since

1986

Affiliations

Johnson & Johnson (United States)(Current)

National Institute of Diabetes and Digestive and Kidney Diseases

Springhouse

Janssen (Belgium)

National Institutes of Health

Bruce Grasberger is an author at Johnson & Johnson (United States) specializing in pharmacology, structural biology, and drug discovery.

Publications per year

1986–2021

16

Publications

16

Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

Bruce Grasberger, Tianbao Lu, Carsten J. Schubert et al. · Journal of Medicinal Chemistry · 2005 · 427 citations · Full text

, , +14

Interaction between proteins localized in membranes.

Bruce Grasberger, Allen P. Minton, Charles DeLisi et al. · Proceedings of the National Academy of Sciences · 1986 · 220 citations · Full text

, , +17

1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2–p53 interaction: discovery and SAR

Daniel J. Parks, Louis V. LaFrance, Raul R. Calvo et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 167 citations

, , +11

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation <i>in vitro</i> and sensitize tumors to doxorubicin <i>in vivo</i>

Holly K. Koblish, Shuyuan Zhao, Carol F. Franks et al. · Molecular Cancer Therapeutics · 2006 · 164 citations · Full text

, , +15

Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution

Céline Schalk‐Hihi, Carsten J. Schubert, Richard Alexander et al. · Protein Science · 2011 · 127 citations · Full text

, , +17

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