Shuyuan Zhao

Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

Bruce Grasberger, Tianbao Lu, Carsten J. Schubert et al. · Journal of Medicinal Chemistry · 2005 · 425 citations · Full text

Molecular Biology, Chemical Biology, Pharmaceutical Chemistry +20

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation <i>in vitro</i> and sensitize tumors to doxorubicin <i>in vivo</i>

Holly K. Koblish, Shuyuan Zhao, Carol F. Franks et al. · Molecular Cancer Therapeutics · 2006 · 162 citations · Full text

P53 Interaction, Chemoprevention Strategy, P53 Complex +18

Altered intestinal microbiome and metabolome correspond to the clinical outcome of sepsis

Silei Sun, Daosheng Wang, Danfeng Dong et al. · Critical Care · 2023 · 78 citations · Full text

Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein–protein interaction through structure-based drug design

Daniel J. Parks, Louis V. LaFrance, Raul R. Calvo et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 76 citations · Full text

Hdm2-p53 Protein–protein Interaction, Drug Target, Medicine +7

IL-17A/IL-17RA promotes invasion and activates MMP-2 and MMP-9 expression via p38 MAPK signaling pathway in non-small cell lung cancer

Zhenhua Wu, Dan He, Shuyuan Zhao et al. · Molecular and Cellular Biochemistry · 2018 · 64 citations

Tumor Biology, Cytokine, Cancer Immunosurveillance +13