Raul R. Calvo

Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

Bruce Grasberger, Tianbao Lu, Carsten J. Schubert et al. · Journal of Medicinal Chemistry · 2005 · 427 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Development of a small RGD peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro

James M. Samanen, F. E. ALI, Todd T. Romoff et al. · Journal of Medicinal Chemistry · 1991 · 193 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2–p53 interaction: discovery and SAR

Daniel J. Parks, Louis V. LaFrance, Raul R. Calvo et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 167 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation <i>in vitro</i> and sensitize tumors to doxorubicin <i>in vivo</i>

Holly K. Koblish, Shuyuan Zhao, Carol F. Franks et al. · Molecular Cancer Therapeutics · 2006 · 164 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic

William H. Miller, Doreen Alberts, Pradip K. Bhatnagar et al. · Journal of Medicinal Chemistry · 1999 · 117 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7