Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

Bruce Grasberger, Tianbao Lu, Carsten J. Schubert, +23

Journal of Medicinal Chemistry

Molecular BiologyChemical BiologyPharmaceutical ChemistryTumor BiologyMolecular Pharmacology +18

Hypoxia induces the expression of the pro-apoptotic gene BNIP3

Ke Guo, George H. Searfoss, David Krolikowski, +6

Cell Death and Differentiation

PhysiologyHypoxia (Medicine)Cell DeathPro-apoptotic Gene Bnip3Redox Biology +4

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation <i>in vitro</i> and sensitize tumors to doxorubicin <i>in vivo</i>

Holly K. Koblish, Shuyuan Zhao, Carol F. Franks, +16

Molecular Cancer Therapeutics

P53 InteractionChemoprevention StrategyP53 ComplexTumor BiologyMedicinal Chemistry +16

JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

Carl L. Manthey, Dana L. Johnson, Carl R. Illig, +21

Molecular Cancer Therapeutics

Solid TumorsImmunologyCancer BiologyTumor BiologyMyeloid Neoplasia +15

Transforming Growth Factor-β-Mediated Apoptosis in the Ramos B-Lymphoma Cell Line Is Accompanied by Caspase Activation and Bcl-XLDownregulation

Alan Saltzman, Robin Munro, George H. Searfoss, +3

Experimental Cell Research

Growth Factor-β-mediated ApoptosisCancer ResearchLymphoid NeoplasiaSignaling PathwayMedicine +10

Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein–protein interaction through structure-based drug design

Daniel J. Parks, Louis V. LaFrance, Raul R. Calvo, +14

Bioorganic & Medicinal Chemistry Letters

Hdm2-p53 Protein–protein InteractionDrug TargetMedicineRational Drug DesignStructure-based Drug Design +5

Cloning and Characterization of Human Jak-2 Kinase: High mRNA Expression in Immune Cells and Muscle Tissue

Alan Saltzman, Maureen Stone, Carol F. Franks, +4

Biochemical and Biophysical Research Communications

Muscle TissueSignal TransductionSignaling PathwayCell RegulationReceptor Tyrosine Kinase +10

The synthesis and SAR of new 4-(N-alkyl-N-phenyl)amino-6,7-dimethoxyquinazolines and 4-(N-alkyl-N-phenyl)aminopyrazolo[3,4-d]pyrimidines, inhibitors of CSF-1R tyrosine kinase activity

Michael R. Myers, Natalie N. Setzer, Alfred P. Spada, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesHeterocycle Chemistry +4

hUBC9 associates with MEKK1 and type I TNF‐α receptor and stimulates NFκB activity

Alan Saltzman, George H. Searfoss, Christophe Marcireau, +8

FEBS Letters

Stimulation of Platelet Production in Healthy Volunteers by a Novel Pegylated Peptide-Based Thrombopoietin (TPO) Receptor Agonist.

Dirk Cerneus, Kathryn H. Brown, Robert A. Harris, +7

Blood