Carol F. Franks

Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

Bruce Grasberger, Tianbao Lu, Carsten J. Schubert et al. · Journal of Medicinal Chemistry · 2005 · 425 citations · Full text

Molecular Biology, Chemical Biology, Pharmaceutical Chemistry +20

Hypoxia induces the expression of the pro-apoptotic gene BNIP3

Ke Guo, George H. Searfoss, David Krolikowski et al. · Cell Death and Differentiation · 2001 · 327 citations · Full text

Physiology, Hypoxia (Medicine), Cell Death +6

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation <i>in vitro</i> and sensitize tumors to doxorubicin <i>in vivo</i>

Holly K. Koblish, Shuyuan Zhao, Carol F. Franks et al. · Molecular Cancer Therapeutics · 2006 · 162 citations · Full text

P53 Interaction, Chemoprevention Strategy, P53 Complex +18

JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

Carl L. Manthey, Dana L. Johnson, Carl R. Illig et al. · Molecular Cancer Therapeutics · 2009 · 107 citations

Solid Tumors, Immunology, Cancer Biology +17

Transforming Growth Factor-β-Mediated Apoptosis in the Ramos B-Lymphoma Cell Line Is Accompanied by Caspase Activation and Bcl-XLDownregulation

Alan Saltzman, Robin Munro, George H. Searfoss et al. · Experimental Cell Research · 1998 · 99 citations

Growth Factor-β-mediated Apoptosis, Cancer Research, Lymphoid Neoplasia +12