Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTDiscovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp MimeticWilliam H. Miller, Doreen P. Alberts, Pradip K. Bhatnagar, William E. Bondinell, James F. Callahan, Raul R. Calvo, Russell D. Cousins, Karl F. Erhard, Dirk A. Heerding, Richard M. Keenan, Chet Kwon, Peter J. Manley, Kenneth A. Newlander, Stephen T. Ross, James M. Samanen, Irene N. Uzinskas, Joseph W. Venslavsky, Catherine C.-K. Yuan, R. Curtis Haltiwanger, Maxine Gowen, Shing-Mei Hwang, Ian E. James, Michael W. Lark, David J. Rieman, George B. Stroup, Leonard M. Azzarano, Kevin L. Salyers, Brian R. Smith, Keith W. Ward, Kyung O. Johanson, and William F. HuffmanView Author Information Research & Development Division, SmithKline Beecham Pharmaceuticals, 1250 South Collegeville Road, P.O. Box 5089, Collegeville, Pennsylvania 19426-0989, and 709 Swedeland Road, P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939 Cite this: J. Med. Chem. 2000, 43, 1, 22–26Publication Date (Web):December 23, 1999Publication History Received30 August 1999Published online23 December 1999Published inissue 1 January 2000https://pubs.acs.org/doi/10.1021/jm990446uhttps://doi.org/10.1021/jm990446urapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1485Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Amides,Antagonists,Assays,Bioavailability,Rodent models Get e-Alerts