Identification of a Selective Nonpeptide Antagonist of the Anaphylatoxin C3a Receptor That Demonstrates Antiinflammatory Activity in Animal Models

Robert S. Ames, Dennis Lee, James J. Foley, +17

The Journal of Immunology

ImmunologyCompetitive AntagonistImmunologic MechanismCellular PharmacologyPharmacotherapy +16

SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist.

Eliot H. Ohlstein, P Nambi, Stephen A. Douglas, +7

Proceedings of the National Academy of Sciences

HypertensionVascular DiseaseReceptor AntagonistPharmacotherapyExperimental Pharmacology +19

1,3-Diarylindan-2-carboxylic Acids, Potent and Selective Non-Peptide Endothelin Receptor Antagonists

John D. Elliott, M. Amparo Lago, Russell D. Cousins, +6

Journal of Medicinal Chemistry

Altmetric Attention ScorePeptide SciencePharmacotherapyExperimental PharmacologyPharmaceutical Chemistry +16

Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic

William H. Miller, Doreen Alberts, Pradip K. Bhatnagar, +28

Journal of Medicinal Chemistry

PharmacotherapyExperimental PharmacologyPharmacodynamic ModelingTranslational PharmacologyPre-clinical Pharmacology +14

Preclinical Pharmacokinetics and Interspecies Scaling of a Novel Vitronectin Receptor Antagonist

Keith W. Ward, Leonard M. Azzarano, William E. Bondinell, +15

Drug Metabolism and Disposition

Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model

William H. Miller, William E. Bondinell, Russell D. Cousins, +26

Bioorganic & Medicinal Chemistry Letters

Bone DiseaseBone HealthOsteoporosis ModelPharmacologyOsteoarthritis +5

Orally bioavailable nonpeptide vitronectin receptor antagonists containing 2-aminopyridine arginine mimetics

Richard M. Keenan, William H. Miller, Linda S. Barton, +10

Bioorganic & Medicinal Chemistry Letters

PharmacologyPharmacological AgentPharmacotherapyNon-peptide Ligand2-Aminopyridine Arginine Mimetics +3

Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists

William H. Miller, Peter J. Manley, Russell D. Cousins, +22

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyPharmaceutical ScienceIntegrin αVβ3MedicineDrug Discovery +4

Lysine 182 of Endothelin B Receptor Modulates Agonist Selectivity and Antagonist Affinity: Evidence for the Overlap of Peptide and Non-peptide Ligand Binding Sites

Jonathan A. Lee, J. Brinkmann, Enrique D. Longton, +6

Biochemistry

Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonists

Richard M. Keenan, William H. Miller, M. Amparo Lago, +17

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryDrug TargetPharmacological StudyBenzimidazole Derivatives +7