p53 Inactivation is a molecular oncogenic event characterized by the functional loss or suppression of the p53 tumor suppressor protein, thereby abrogating its role in cell cycle regulation, DNA repair, and apoptosis induction in response to cellular stress.
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Bert Vogelstein, David P. Lane, Arnold J. Levine · Nature · 2000 · 6.6K citations
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations
Mdm2 promotes the rapid degradation of p53
Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
David Malkin, Frederick P. Li, Louise C. Strong et al. · Science · 1990 · 3.8K citations
Life Sciences, Genetics, Oncology +17
Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.
Marc S. Greenblatt, W P Bennett, Monica Hollstein et al. · PubMed · 1994 · 3.5K citations
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- GLGuillermina Lozano
The University of Texas MD Anderson Cancer Center, United States
43 publications · 9K citations
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- VR
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Harvard University
Cambridge, United States
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The University of Texas MD Anderson Cancer Center
Houston, United States
83 h-index
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National Cancer Institute
Bethesda, United States
78 h-index
587 publications
92K citations
Howard Hughes Medical Institute
Chevy Chase, United States
77 h-index
326 publications
97.9K citations
Weizmann Institute of Science
Rehovot, Israel
70 h-index
512 publications
102.7K citations
Dana-Farber Cancer Institute
Boston, United States
70 h-index
427 publications
88.8K citations
National Institutes of Health
Bethesda, United States
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504 publications
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Inserm
Paris, France
59 h-index
690 publications
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PNAS · 172 publications · 28.4K citations
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- Journal of Biological Chemistry
JBC · 223 publications · 20.3K citations
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- The EMBO Journal
91 publications · 20.8K citations
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