Gaël Krysa

Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors

Françoise Gellibert, James M. Woolven, Marie-Hélène Fouchet et al. · Journal of Medicinal Chemistry · 2004 · 217 citations · Full text

Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)

Jonathan T. Seal, Yann Lamotte, Frédéric Donche et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 207 citations · Full text

Novel Series, Medicine, Chemical Biology +4

The Discovery of I-BET726 (GSK1324726A), a Potent Tetrahydroquinoline ApoA1 Up-Regulator and Selective BET Bromodomain Inhibitor

Romain Gosmini, Van Loc Nguyen, Jérôme Toum et al. · Journal of Medicinal Chemistry · 2014 · 187 citations · Full text

Medicinal Chemistry, Histone Code, Drug Target +12

Inhibition of TGF‐<i>β</i> signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine‐induced liver fibrosis

Anne‐Charlotte de Gouville, Valérie Boullay, Gaël Krysa et al. · British Journal of Pharmacology · 2005 · 164 citations · Full text

Liver Fibrosis, Human Growth, Pathology +18

From ApoA1 upregulation to BET family bromodomain inhibition: Discovery of I-BET151

Olivier Mirguet, Yann Lamotte, Frédéric Donche et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 118 citations · Full text

Transcriptional Regulation, Genetics, Immunology +4