Jonathan T. Seal

Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)

Jonathan T. Seal, Yann Lamotte, Frédéric Donche et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 207 citations · Full text

Novel Series, Medicine, Chemical Biology +4

Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides

Paul Bamborough, Hawa Diallo, Jonathan D. Goodacre et al. · Journal of Medicinal Chemistry · 2011 · 176 citations · Full text

Combinatorial Chemistry, Drug Target, Bioorganic Chemistry +19

From ApoA1 upregulation to BET family bromodomain inhibition: Discovery of I-BET151

Olivier Mirguet, Yann Lamotte, Frédéric Donche et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 118 citations · Full text

Transcriptional Regulation, Genetics, Immunology +4

The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor

Jonathan T. Seal, Stephen J. Atkinson, Helen Aylott et al. · Journal of Medicinal Chemistry · 2020 · 63 citations · Full text

Design and Synthesis of a Highly Selective and <i>In Vivo</i>-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins

Alex Preston, Stephen J. Atkinson, Paul Bamborough et al. · Journal of Medicinal Chemistry · 2020 · 52 citations · Full text