Alex Preston

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation

Omer Gilan, Inmaculada Rioja, Kathy Knezevic et al. · Science · 2020 · 411 citations · Full text

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-<i>d</i>]pyrimidin-4(3<i>H</i>)-one Derivatives

Susan M. Westaway, Alex Preston, Michael D. Barker et al. · Journal of Medicinal Chemistry · 2016 · 67 citations · Full text

Drug Target, Molecular Biology, Kdm5 Families +18

The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor

Jonathan T. Seal, Stephen J. Atkinson, Helen Aylott et al. · Journal of Medicinal Chemistry · 2020 · 63 citations · Full text

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives

Susan M. Westaway, Alex Preston, Michael D. Barker et al. · Journal of Medicinal Chemistry · 2016 · 59 citations · Full text

Mechanistic Kdm4c Cell, Molecular Biology, Kdm5 Families +17

Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor

John Liddle, Francis Atkinson, Michael D. Barker et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 52 citations · Full text

G Protein-coupled Receptor, Medicine, Receptor Tyrosine Kinase +5