Frédéric Donche

Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)

Jonathan T. Seal, Yann Lamotte, Frédéric Donche et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 207 citations · Full text

Novel Series, Medicine, Chemical Biology +4

From ApoA1 upregulation to BET family bromodomain inhibition: Discovery of I-BET151

Olivier Mirguet, Yann Lamotte, Frédéric Donche et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 118 citations · Full text

Transcriptional Regulation, Genetics, Immunology +4

Substituted 2-[(4-Aminomethyl)phenoxy]-2-methylpropionic Acid PPARα Agonists. 1. Discovery of a Novel Series of Potent HDLc Raising Agents

Michael L. Sierra, Véronique Bénéton, Anne-Bénédict Boullay et al. · Journal of Medicinal Chemistry · 2007 · 117 citations · Full text

Pharmaceutical Science, Potent Hdlc, Restricted Selectivity +19

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase

Philip A. Harris, Nicolas Faucher, Nicolas George et al. · Journal of Medicinal Chemistry · 2019 · 68 citations · Full text

Drug Target, Immunology, Efficacious Inhibitors +19

Design and evaluation of a novel series of 2,3-oxidosqualene cyclase inhibitors with low systemic exposure, relationship between pharmacokinetic properties and ocular toxicity

Marie-Hélène Fouchet, Frédéric Donche, Christelle Martin et al. · Bioorganic & Medicinal Chemistry · 2008 · 16 citations · Full text

Medicinal Chemistry, Ocular Toxicity, Pharmacological Study +12