Romain Gosmini

Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

Chun‐wa Chung, Hervé Coste, Julia H. White et al. · Journal of Medicinal Chemistry · 2011 · 334 citations · Full text

Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains

Olivier Mirguet, Romain Gosmini, Jérôme Toum et al. · Journal of Medicinal Chemistry · 2013 · 301 citations · Full text

Histone Modifications, Chemoprevention Strategy, Epigenetic Change +22

BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models

Anastasia Wyce, Gopinath Ganji, Kimberly N. Smitheman et al. · PLoS ONE · 2013 · 203 citations · Full text

Mycn Copy Number, Bet Family Proteins, Cell Regulation +14

The Discovery of I-BET726 (GSK1324726A), a Potent Tetrahydroquinoline ApoA1 Up-Regulator and Selective BET Bromodomain Inhibitor

Romain Gosmini, Van Loc Nguyen, Jérôme Toum et al. · Journal of Medicinal Chemistry · 2014 · 187 citations · Full text

Medicinal Chemistry, Histone Code, Drug Target +12

From ApoA1 upregulation to BET family bromodomain inhibition: Discovery of I-BET151

Olivier Mirguet, Yann Lamotte, Frédéric Donche et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 118 citations · Full text

Transcriptional Regulation, Genetics, Immunology +4