Jorge Kirilovsky

Suppression of inflammation by a synthetic histone mimic

Edwige Nicodème, Kate L. Jeffrey, Uwe Schaefer et al. · Nature · 2010 · 1.6K citations · Full text

Life Sciences, Immunology, Molecular Biology +12

Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

Chun‐wa Chung, Hervé Coste, Julia H. White et al. · Journal of Medicinal Chemistry · 2011 · 335 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17

The Discovery of Tadalafil:  A Novel and Highly Selective PDE5 Inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1‘,2‘:1,6]pyrido[3,4-<i>b</i>]indole-1,4-dione Analogues

Alain Daugan, Pascal Grondin, Cécile Ruault et al. · Journal of Medicinal Chemistry · 2003 · 282 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)

Jonathan T. Seal, Yann Lamotte, Frédéric Donche et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 213 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

The Discovery of Tadalafil:  A Novel and Highly Selective PDE5 Inhibitor. 1: 5,6,11,11a-Tetrahydro-1<i>H</i>-imidazo[1‘,5‘:1,6]pyrido[3,4-<i>b</i>]indole-1,3(2<i>H</i>)-dione Analogues

Alain Daugan, Pascal Grondin, Cécile Ruault et al. · Journal of Medicinal Chemistry · 2003 · 194 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16