Concepedia

α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins. 1. Survey of Natural Pigments with Potent Inhibitory Activity

Toshiro Matsui, Tetsuya Ueda, Tomoyuki Oki, Koichi Sugita, Norihiko Terahara, Kiyoshi Matsumoto

Journal of Agricultural and Food Chemistry · 2001 · 394 citations · 9 references

DOI

Concepts

TL;DR

The study evaluated α‑glucosidase inhibition by natural anthocyanin extracts. Twelve anthocyanin extracts displayed strong α‑glucosidase inhibition, with Pharbitis nil (SOA) and Ipomoea batatas (YGM) showing the lowest IC50 values (0.35 and 0.36 mg mL⁻¹) in free assays, neither affecting sucrase, while in an immobilized assay SOA and YGM exhibited even lower IC50s (0.17 and 0.26 mg mL⁻¹) and both extracts also inhibited α‑amylase, indicating potential post‑prandial glucose suppression. Keywords: α‑glucosidase, anthocyanins, inhibition, non‑insulin‑dependent diabetes mellitus.

Abstract

α-Glucosidase (AGH) inhibitory study by natural anthocyanin extracts was done. As the result of a free AGH assay system, 12 anthocyanin extracts were found to have a potent AGH inhibitory activity; in particular, Pharbitis nil (SOA) extract showed the strongest maltase inhibitory activity, with an IC50 value of 0.35 mg/mL, as great as that of Ipomoea batatas (YGM) extract (IC50 = 0.36 mg/mL). Interestingly, neither extract inhibited the sucrase activity at all. For the immobilized assay system, which may reflect the pharmacokinetics of AGH at the small intestine, SOA and YGM extracts gave more potent maltase inhibitory activities than those of the free AGH assay, with IC50 values of 0.17 and 0.26 mg/mL, respectively. Both extracts also inhibited α-amylase action, indicating that anthocyanins would have a potential function to suppress the increase in postprandial glucose level from starch. Keywords: α-Glucosidase; anthocyanins; inhibition; non-insulin-dependent diabetes mellitus

References

9

Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris L

Takanori Tsuda, Kaoru Shiga, Katsumi Ohshima et al. · Biochemical Pharmacology · 1996 · 365 citations

, , +16

<i>In Vitro</i>Survey of<i>α</i>-Glucosidase Inhibitory Food Components

Toshiro Matsui, Chiho Yoshimoto, Katsuhiro Osajima et al. · Bioscience Biotechnology and Biochemistry · 1996 · 228 citations · Full text

, , +14

l-Arabinose selectively inhibits intestinal sucrase in an uncompetitive manner and suppresses glycemic response after sucrose ingestion in animals

Kenji Seri, Kazuko Sanai, Noriki Matsuo et al. · Metabolism · 1996 · 194 citations

, , +17

Six Diacylated Anthocyanins from the Storage Roots of Purple Sweet Potato,<i>Ipomoea batatas</i>

Norihiko Terahara, Takashige Shimizu, Yoshiaki Kato et al. · Bioscience Biotechnology and Biochemistry · 1999 · 114 citations · Full text

, , +13

Biosynthesis of sucrase-isomaltase. Purification and NH2-terminal amino acid sequence of the rat sucrase-isomaltase precursor (pro-sucrase-isomaltase) from fetal intestinal transplants.

H P Hauri, Hans Wacker, Egon E. Rickli et al. · Journal of Biological Chemistry · 1982 · 103 citations · Full text

, , +13