Concepedia

Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing

Benedetta Artegiani, Delilah Hendriks, Joep Beumer, Rutger N.U. Kok, Xuan Zheng, Indi P. Joore, Susana M. Chuva de Sousa Lopes, Jeroen S. van Zon, Sander J. Tans, Hans Clevers

Nature Cell Biology · 2020 · 284 citations · 48 references

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48

Genome engineering using the CRISPR-Cas9 system

F. Ann Ran, Patrick D. Hsu, Jason Wright et al. · Nature Protocols · 2013 · 11.7K citations · Full text

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Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

Toshiro Sato, Daniel E. Stange, Marc Ferrante et al. · Gastroenterology · 2011 · 3.8K citations · Full text

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Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Meritxell Huch, Helmuth Gehart, Ruben van Boxtel et al. · Cell · 2014 · 1.6K citations · Full text

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Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

Gerald Schwank, Bon‐Kyoung Koo, Valentina Sasselli et al. · Cell stem cell · 2013 · 1.4K citations · Full text

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CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

Emma Haapaniemi, Sandeep K. Botla, Jenna Persson et al. · Nature Medicine · 2018 · 1.3K citations · Full text

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