Bon‐Kyoung Koo

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

Laura Broutier, Gianmarco Mastrogiovanni, Monique M.A. Verstegen et al. · Nature Medicine · 2017 · 1.4K citations · Full text

Hepatology, Preclinical Models, Liver Physiology +14

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

Gerald Schwank, Bon‐Kyoung Koo, Valentina Sasselli et al. · Cell stem cell · 2013 · 1.4K citations · Full text

Fibrosis, Cystic Fibrosis Patients, Functional Repair +7

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

Wim de Lau, Nick Barker, Teck Yew Low et al. · Nature · 2011 · 1.3K citations

Signal Transduction, Signaling Pathway, Wnt Receptors +7

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

Bon‐Kyoung Koo, Maureen Spit, Ingrid Jordens et al. · Nature · 2012 · 967 citations · Full text

Signaling Pathway, Cell Regulation, Wnt Receptors +11

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

Laura Broutier, Amanda Andersson-Rolf, Christopher J. Hindley et al. · Nature Protocols · 2016 · 840 citations · Full text

Regenerative Medicine, Developmental Biology, Medicine +11