Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, +20

Cell

Enormous Replication PotentialAdult Stem CellExpanded CellsOrgan DevelopmentCholangiopathies +26

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

Huili Hu, Helmuth Gehart, Benedetta Artegiani, +17

Cell

Regenerative MedicineHuman CellDevelopmental BiologyHepatologyEngineering +13

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping

Helmuth Gehart, Johan H. van Es, Karien M. Hamer, +5

Cell

Signal TransductionMolecular PhysiologyMedicineEnteroendocrine RegulatorsCell Manipulation +4

Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma

Elisa De Crignis, Tanvir Hossain, Shahla Romal, +20

eLife

Viral ReplicationImmunologyHepatitis BPathologyMolecular Biology +22

Exploring the human lacrimal gland using organoids and single-cell sequencing

Marie Bannier-Hélaouët, Yorick Post, Jeroen Korving, +8

Cell stem cell

BioinformaticsDna SequencingHuman CellHuman Lacrimal GlandMedicine +7

Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1

Marc A. Kerenyi, Florian Grebien, Helmuth Gehart, +6

Blood

NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor

Laura Novellasdemunt, Anna Kucharská, Cara Jamieson, +7

The EMBO Journal

The BAR Domain Protein Arfaptin-1 Controls Secretory Granule Biogenesis at the trans-Golgi Network

Helmuth Gehart, Alexander Goginashvili, Rainer Beck, +7

Developmental Cell

Protein SecretionProtein FunctionSignal TransductionMedicineNatural Sciences +10

Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung

Arne Ittner, Helena Block, Christoph A. Reichel, +7

The Journal of Experimental Medicine

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Monique M.A. Verstegen, Floris J.M. Roos, Ksenia Burka, +23

Scientific Reports