Concepedia

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

Tony P. Huang, Kevin T. Zhao, Shannon M. Miller, Nicole M. Gaudelli, Benjamin L. Oakes, Christof Fellmann, David F. Savage, David R. Liu

Nature Biotechnology · 2019 · 324 citations · 34 references

DOI

Concepts

References

34

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shikshya Shrestha, Steven M. Offer · Medical Epigenetics · 2016 · 9K citations · Full text

, , +17

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Alexis C. Komor, Y. Bill Kim, Michael S. Packer et al. · Nature · 2016 · 5.4K citations · Full text

, , +9

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

Bernd Zetsche, Jonathan S. Gootenberg, Omar O. Abudayyeh et al. · Cell · 2015 · 4.9K citations · Full text

, , +12

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Nicole M. Gaudelli, Alexis C. Komor, Holly A. Rees et al. · Nature · 2017 · 4.2K citations · Full text

, , +12

ClinVar: public archive of relationships among sequence variation and human phenotype

Melissa Landrum, Jennifer M. Lee, Wonhee Jang et al. · Nucleic Acids Research · 2013 · 3.7K citations · Full text

, , +16