Tony P. Huang

Continuous evolution of SpCas9 variants compatible with non-G PAMs

Shannon M. Miller, Tina Wang, Peyton B. Randolph et al. · Nature Biotechnology · 2020 · 357 citations · Full text

Life Sciences, Genetics, Molecular Genetics +8

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

Tony P. Huang, Kevin T. Zhao, Shannon M. Miller et al. · Nature Biotechnology · 2019 · 324 citations

Life Sciences, Biotechnology, Molecular Genetics +10

Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity

Monica E. Neugebauer, Alvin Hsu, Mandana Arbab et al. · Nature Biotechnology · 2022 · 263 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA

Beverly Mok, Anna V. Kotrys, Aditya Raguram et al. · Nature Biotechnology · 2022 · 207 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors

Jessie R. Davis, Xiao Wang, Isaac P. Witte et al. · Nature Biomedical Engineering · 2022 · 187 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17