Engineered pegRNAs improve prime editing efficiency

James W. Nelson, Peyton B. Randolph, Simon P. Shen, +8

Nature Biotechnology

Natural SciencesMolecular BiologyGene EditingSmall RnaGene Expression +3

Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity

Monica E. Neugebauer, Alvin Hsu, Mandana Arbab, +11

Nature Biotechnology

Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease

Kiran Musunuru, Sarah Grandinette, Xiao Wang, +41

New England Journal of Medicine

Genetic DiseasesGenome SurgeryIn Vivo Gene TherapyNovel TherapyGenetics +13

Branched chemically modified poly(A) tails enhance the translation capacity of mRNA

Hongyu Chen, Dangliang Liu, Jianting Guo, +11

Nature Biotechnology

Translation CapacityEngineeringNucleic Acid ChemistryNatural SciencesRna Biology +7

High-throughput evaluation of genetic variants with prime editing sensor libraries

Samuel I. Gould, Alexandra Wuest, Kexin Dong, +7

Nature Biotechnology

GeneticsMolecular BiologyTumor GenomesGenomicsGenetic Analysis +20

Xanthone derivatives could be potential antibiotics: virtual screening for the inhibitors of enzyme I of bacterial phosphoenolpyruvate-dependent phosphotransferase system

Kuo-Jien Huang, Shih‐Hung Lin, Meei‐Ru Lin, +5

The Journal of Antibiotics

Virtual ScreeningAntibioticsBiochemistryMedicinePotential Antibiotics +8

Generating experimentally unrelated target molecule-binding highly functionalized nucleic-acid polymers using machine learning

Jonathan C. Chen, Jonathan P. Chen, Max W. Shen, +5

Nature Communications

Base editing of trinucleotide repeats that cause Huntington’s disease and Friedreich’s ataxia reduces somatic repeat expansions in patient cells and in mice

Żaneta Matuszek, Mandana Arbab, Maheswaran Kesavan, +18

Nature Genetics

High throughput evaluation of genetic variants with prime editing sensor libraries

Samuel I. Gould, Alexandra Wuest, Kexin Dong, +6