Isaac P. Witte

Programmed DNA destruction by miniature CRISPR-Cas14 enzymes

Lucas B. Harrington, David Burstein, Janice S. Chen et al. · Science · 2018 · 1.2K citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors

Jessie R. Davis, Xiao Wang, Isaac P. Witte et al. · Nature Biomedical Engineering · 2022 · 187 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17

CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks

Joshua C. Cofsky, Deepti Karandur, Carolyn J. Huang et al. · eLife · 2020 · 121 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase

Isaac P. Witte, George D. Lampe, Simon Eitzinger et al. · Science · 2025 · 78 citations · Full text

Life Sciences, Biotechnology, Genetics +14

A scoutRNA Is Required for Some Type V CRISPR-Cas Systems

Lucas B. Harrington, Enbo Ma, Janice S. Chen et al. · Molecular Cell · 2020 · 76 citations · Full text

Life Sciences, Genetics, Molecular Biology +9