Isaac P. Witte

Programmed DNA destruction by miniature CRISPR-Cas14 enzymes

Lucas B. Harrington, David Burstein, Janice S. Chen et al. · Science · 2018 · 1.2K citations · Full text

Programmed Dna Destruction, Off-target Effect, Engineering +15

Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors

Jessie R. Davis, Xiao Wang, Isaac P. Witte et al. · Nature Biomedical Engineering · 2022 · 169 citations · Full text

CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks

Joshua C. Cofsky, Deepti Karandur, Carolyn J. Huang et al. · eLife · 2020 · 118 citations · Full text

A scoutRNA Is Required for Some Type V CRISPR-Cas Systems

Lucas B. Harrington, Enbo Ma, Janice S. Chen et al. · Molecular Cell · 2020 · 74 citations · Full text

Engineering, Genetics, Molecular Biology +8

Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase

Isaac P. Witte, George D. Lampe, Simon Eitzinger et al. · Science · 2025 · 48 citations · Full text