Joshua C. Cofsky

Programmed DNA destruction by miniature CRISPR-Cas14 enzymes

Lucas B. Harrington, David Burstein, Janice S. Chen et al. · Science · 2018 · 1.2K citations · Full text

Programmed Dna Destruction, Off-target Effect, Engineering +15

A Broad-Spectrum Inhibitor of CRISPR-Cas9

Lucas B. Harrington, Kevin Doxzen, Enbo Ma et al. · Cell · 2017 · 263 citations · Full text

Broad-spectrum Inhibitor, Molecular Biology, Genetic Engineering +5

Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme

Gavin J. Knott, Alexandra East-Seletsky, Joshua C. Cofsky et al. · Nature Structural & Molecular Biology · 2017 · 170 citations · Full text

Guide-bound Structures, Molecular Biology, Gene Editing +4

Deconstruction of the Ras switching cycle through saturation mutagenesis

Pradeep Bandaru, Neel H. Shah, Moitrayee Bhattacharyya et al. · eLife · 2017 · 129 citations · Full text

Genetics, Genomic Mechanism, Molecular Biology +21

Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling

Ivan E. Ivanov, Addison V. Wright, Joshua C. Cofsky et al. · Proceedings of the National Academy of Sciences · 2020 · 118 citations · Full text

Crispr-cas9 Nuclease, Genetics, Dna Analysis +21