Michael S. Packer

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Alexis C. Komor, Y. Bill Kim, Michael S. Packer et al. · Nature · 2016 · 5.2K citations · Full text

Engineering, Genetics, Synthetic Biology +11

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Nicole M. Gaudelli, Alexis C. Komor, Holly A. Rees et al. · Nature · 2017 · 4K citations · Full text

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions

Y. Bill Kim, Alexis C. Komor, Jonathan M. Levy et al. · Nature Biotechnology · 2017 · 775 citations · Full text

Engineering, Cas9-cytidine Deaminase Fusions, Synthetic Biology +10

Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

Alexis C. Komor, Kevin T. Zhao, Michael S. Packer et al. · Science Advances · 2017 · 759 citations · Full text

Directed evolution of adenine base editors with increased activity and therapeutic application

Nicole M. Gaudelli, Dieter K. Lam, Holly A. Rees et al. · Nature Biotechnology · 2020 · 505 citations

Medicinal Chemistry, Pharmaceutical Chemistry, Biochemistry +10