Nicole M. Gaudelli

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Nicole M. Gaudelli, Alexis C. Komor, Holly A. Rees et al. · Nature · 2017 · 4K citations · Full text

Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

Alexis C. Komor, Kevin T. Zhao, Michael S. Packer et al. · Science Advances · 2017 · 759 citations · Full text

In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates

Kiran Musunuru, Alexandra C. Chadwick, Taiji Mizoguchi et al. · Nature · 2021 · 713 citations

Knockout Mouse, Genetics, Genetic Engineering +8

Directed evolution of adenine base editors with increased activity and therapeutic application

Nicole M. Gaudelli, Dieter K. Lam, Holly A. Rees et al. · Nature Biotechnology · 2020 · 505 citations

Medicinal Chemistry, Pharmaceutical Chemistry, Biochemistry +10

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

Tony P. Huang, Kevin T. Zhao, Shannon M. Miller et al. · Nature Biotechnology · 2019 · 316 citations

Engineering, Pam-modified Cas9 Variants, Molecular Biology +6