Alexandra C. Chadwick

In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates

Kiran Musunuru, Alexandra C. Chadwick, Taiji Mizoguchi et al. · Nature · 2021 · 713 citations

Knockout Mouse, Genetics, Genetic Engineering +8

In Vivo Base Editing of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) as a Therapeutic Alternative to Genome Editing

Alexandra C. Chadwick, Xiao Wang, Kiran Musunuru · Arteriosclerosis Thrombosis and Vascular Biology · 2017 · 215 citations · Full text

In utero CRISPR-mediated therapeutic editing of metabolic genes

Avery C. Rossidis, John D. Stratigis, Alexandra C. Chadwick et al. · Nature Medicine · 2018 · 213 citations · Full text

Engineering, Genome Surgery, Medicine +8

CD8+ Foxp3+ Regulatory T Cells Are Induced during Graft-versus-Host Disease and Mitigate Disease Severity

Amy Beres, Dipica Haribhai, Alexandra C. Chadwick et al. · The Journal of Immunology · 2012 · 118 citations · Full text

Cell Therapy, T-regulatory Cell, Immunology +16

GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy

Lisa N. Kasiewicz, Souvik Biswas, Aaron Beach et al. · Nature Communications · 2023 · 117 citations · Full text

Nanoparticles, Nanotherapeutics, Engineering +18