Lisa N. Kasiewicz

In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates

Kiran Musunuru, Alexandra C. Chadwick, Taiji Mizoguchi et al. · Nature · 2021 · 713 citations

Knockout Mouse, Genetics, Genetic Engineering +8

GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy

Lisa N. Kasiewicz, Souvik Biswas, Aaron Beach et al. · Nature Communications · 2023 · 117 citations · Full text

Nanoparticles, Nanotherapeutics, Engineering +18

Lipid nanoparticles silence tumor necrosis factor α to improve wound healing in diabetic mice

Lisa N. Kasiewicz, Kathryn A. Whitehead · Bioengineering & Translational Medicine · 2018 · 80 citations · Full text

Nanoparticles, Nanotherapeutics, Engineering +26

Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d

Namit Chaudhary, Lisa N. Kasiewicz, Alexandra N. Newby et al. · Nature Biomedical Engineering · 2024 · 75 citations · Full text

Lipid Preparation, Nanomedicine, Proteinlipid Interaction +9

Silencing TNFα with lipidoid nanoparticles downregulates both TNFα and MCP-1 in an in vitro co-culture model of diabetic foot ulcers

Lisa N. Kasiewicz, Kathryn A. Whitehead · Acta Biomaterialia · 2015 · 60 citations

Inflammation, Vitro Co-culture Model, Anti-inflammatory +9