Chemical composition and antiproliferative, antioxidant and trypanocidal activities of the fruits from <i>Campomanesia xanthocarpa</i> (Mart.) O. Berg (Myrtaceae)

Abstract

Chemical investigation of the extracts of the fruits from <i>Campomanesia xanthocarpa</i> resulted in the isolation of six known compounds identified by NMR and comparison with literature data (2',4'-dihydroxy-5'-methyl-6'-methoxychalcone (<b>1</b>), 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone (<b>2</b>), 2'-hydroxy-3'-methyl-4',6'-dimethoxychalcone (<b>3</b>), 2',6'-dihydroxy-3'-methyl-4'-methoxychalcone (<b>4</b>), 5-hydroxy-7-methoxy-8-methylflavanone (<b>5</b>) and 7-hydroxy-5-methoxy-6-methylflavanone (<b>6</b>)). The considerable antioxidant capacity of the extracts was demonstrated by ORAC-FL and DPPH tests. The antiproliferative assay of the extracts and <b>5</b> was done <i>in vitro</i>, against many different cancer cell lines besides a healthy one. The extracts presented low cytotoxicity and the substance demonstrated promising results against all the cancer cell lines tested, with IC₅₀ values ranging from 4.75 to 45.81 µmol L^-1. The <i>in vitro</i> trypanocidal activity was evaluated against the epimastigote form of the Y strain of <i>Trypanosoma cruzi</i> and an improvement in the activity of the substances <b>2</b> (221.81 µmol L^-1) and <b>5</b> (61.87 µmol L^-1) was observed regarding the values obtained for the extracts.