Concepedia

An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities

Jason M. Gehrke, Oliver Cervantes, Kendell Clement, Yuxuan Wu, Jing Zeng, Daniel E. Bauer, Luca Pinello, J. Keith Joung

Nature Biotechnology · 2018 · 451 citations · 27 references

DOI

Concepts

References

27

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Alexis C. Komor, Y. Bill Kim, Michael S. Packer et al. · Nature · 2016 · 5.4K citations · Full text

, , +9

In vivo genome editing using Staphylococcus aureus Cas9

F. Ann Ran, Le Cong, Winston X. Yan et al. · Nature · 2015 · 2.7K citations · Full text

, , +11

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

Benjamin P. Kleinstiver, Vikram Pattanayak, Michelle S. Prew et al. · Nature · 2016 · 2.7K citations · Full text

, , +14

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

Sangsu Bae, Jeongbin Park, Jin‐Soo Kim · Bioinformatics · 2014 · 2.4K citations · Full text

, , +13

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

Shengdar Q. Tsai, Zongli Zheng, Nathalie T. Nguyen et al. · Nature Biotechnology · 2014 · 2.3K citations · Full text

, , +14