Concepedia

Off-target Effects

Off-Target Effects is a phenomenon in genome editing wherein the editing agent introduces unintended modifications at genomic sites other than the intended target locus, due to sequence similarity or structural factors.

488

Publications

67.1K

Citations

2.9K

Authors

795

Institutions

Publications per year

2017–2026

374

Parents

Children

Publications

488

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

Yanfang Fu, Jennifer A Foden, Cyd Khayter et al. · Nature Biotechnology · 2013 · 3.3K citations · Full text

, , +16

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

Benjamin P. Kleinstiver, Vikram Pattanayak, Michelle S. Prew et al. · Nature · 2016 · 2.7K citations · Full text

, , +14

Rationally engineered Cas9 nucleases with improved specificity

Ian M. Slaymaker, Linyi Gao, Bernd Zetsche et al. · Science · 2015 · 2.5K citations

, , +15

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

Sangsu Bae, Jeongbin Park, Jin‐Soo Kim · Bioinformatics · 2014 · 2.4K citations · Full text

, , +13

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

Shengdar Q. Tsai, Zongli Zheng, Nathalie T. Nguyen et al. · Nature Biotechnology · 2014 · 2.3K citations · Full text

, , +14

1–5 of 488

Authors

2.9K

  1. JK
    Jin‐Soo Kim

    Seoul National University, South Korea

    19 publications · 7.8K citations

    15

    h-index

  2. JK
    J. Keith Joung

    Massachusetts General Hospital, United States

    17 publications · 11.5K citations

    14

    h-index

  3. DR
    David R. Liu

    Harvard University, United States

    13 publications · 2.8K citations

    13

    h-index

  4. XH
    Xingxu Huang

    ShanghaiTech University, China

    10 publications · 1.9K citations

    11

    h-index

  5. SB
    Sangsu Bae

    Hanyang University, South Korea

    10 publications · 5.4K citations

    10

    h-index

1–5 of 2.9K

Institutions

795

  1. Harvard University

    Cambridge, United States

    39 h-index

    203 publications

    87.3K citations

  2. Broad Institute

    Cambridge, United States

    27 h-index

    125 publications

    33K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    23 h-index

    99 publications

    22.8K citations

  4. Chinese Academy of Sciences

    Beijing, China

    20 h-index

    109 publications

    14.9K citations

  5. Massachusetts General Hospital

    Boston, United States

    20 h-index

    137 publications

    91.3K citations

  6. Seoul National University

    Seoul, South Korea

    15 h-index

    53 publications

    28.8K citations

  7. Center for Cancer Research

    Bethesda, United States

    15 h-index

    110 publications

    84.5K citations

  8. Institute for Basic Science

    Daejeon, South Korea

    14 h-index

    50 publications

    8K citations

1–8 of 795

Venues

  1. Nature Communications

    59 publications · 5.3K citations

    42

    h-index

  2. Nucleic Acids Research

    41 publications · 6.6K citations

    31

    h-index

  3. Nature Biotechnology

    24 publications · 11.4K citations

    22

    h-index

  4. Molecular Therapy

    19 publications · 1.3K citations

    17

    h-index

  5. Scientific Reports

    18 publications · 1.2K citations

    16

    h-index

1–5